A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery
Hoare, Todd · Santamaria, Jesus · Goya, Gerardo F. · Irusta, Silvia · Lin, Debora · Lau, Samantha · Padera, Robert · Langer, Robert · Kohane, Daniel S.
Original · EN
Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were non-cytotoxic, biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.
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