Soliton mediated protein folding

الأصل · EN

A novel approach to protein folding dynamics is presented. We suggest that folding of protein may be mediated via interaction with solitons which propagate along the molecular chain. A simple toy model is presented in which a Sine-Gordon field interact with another field corresponding to the conformation angles of the protein. We demonstrate how a soliton carries this field over energy barriers and consequently enhances the rate of the folding process. The soliton compensate for its energy loss by pumping the energy gained by the folded field. This scenario does not change significantly even in the presence of dissipation and imposed disorder.