A New Look at Dynamic Force Spectroscopy of Adhesion Bonds

Original · EN

Dynamic force spectroscopy of single molecules is described by a model which predicts a distribution of rupture forces, the corresponding mean rupture force and variance, all amenable to experimental tests. The distribution has a pronounced asymmetry which has recently been observed experimentally. The mean rupture force follows a lnV to the power of 2/3 dependence on the pulling velocity V and differs from earlier predictions.Interestingly, at low pulling velocities a rebinding process is obtained whose signature is an intermittent behavior of the spring force which delays the rupture. An extension to include conformational changes of the adhesion complex is proposed which leads to the possibility of bimodal distributions of rupture forces.