Temperature- and Force-Induced beta-Sheet Unfolding in an Exactly Solvable Model
Zhou, Haijun
Original · EN
The stability of a β-sheeted conformation and its transition into a random coil are studied with a 2D lattice biopolymer model. At low temperature and low external force, the polymer folds back and forth on itself and forms a β-sheet. Our analytical calculation and Monte Carlo simulation reveal that a co-operative β-sheet--random coil transition takes places when the temperature or force is increased, with a dramatic decrease in the contact number. These predictions are in good agreement with experiments on titin protein. This transition is not a real phase-transition, indicating that backbone hydrogen-bonding alone is unable to stabilize a distinct β-sheet phase.
English translation
This paper has no Arabic translation yet. Be the first: it takes a few seconds, and the result is stored for every future reader.